Ap biology protein synthesis essay

Chloroplast and Thylakoid In photosynthetic bacteria, the proteins that gather light for photosynthesis are embedded in cell membranes. In its simplest form, this involves the membrane surrounding the cell itself. A typical plant cell contains about 10 to chloroplasts.

Ap biology protein synthesis essay

Mitogens substances outside the cell which stimulate cell Ap biology protein synthesis essay and growth factors usually act on cell surface receptors to activate signalling molecules which affect gene transcription leading to accelerated cell growth.

Oncogene proteins are also present in the intracellular signalling from integrins surface proteins mediating cell motility, attachment and associated growth signals. Whereas tumor suppressor gene mutations can be described as "faulty brakes", oncogenes can be characterized as "stuck accelerator pedal".

Most growth factors act by binding to transmembrane tyrosine kinase receptors on the cell surface membrane. From the point of view of cancer, the most notable cell signalling pathway is the one activated by the Ras protein attached to the inner cell surface associated with the tyrosine kinase receptor.

Oncogenes of the Ras protein mutated proto-oncogenes cause Ras to be perpetually active, whether a growth factor is present or at the tyrosine kinase receptor or not.

Search by Course Title, Number or Instructor Last Name:

Nearly a third of all human cancers have the ras oncogene, forming a defective Ras protein. Both the p53 tumor-suppressor gene and the ras oncogene promote VEGF secretion — promoting angiogenesis growth of new blood vessels required to support new, rapidly-growing cancer tissue.

Cell Receptor Signalling to the Nuclear Transcription Factors The transcription factor proteins Fos, Jun and Myc come from proto-oncogenes designated as immediate early genes because they are expressed rapidly after mitogen stimulation and have a short half-life. The proteins from immediate early genes are transcription factors produced in response to cell stimuli, and these transcription factors cause the production of functional proteins.

Oncogenes produced mutated forms of the immediate early genes which can increase the activity of the proteins they form. Overexpression of the Myc growth factor can lead to the angiogenesis and tumor-cell invasiveness that characterizes malignancy.

Myc overexpression increases Bcl2 protein and decreases p53 protein, both effects being anti-apoptotic and pro-proliferative. Myc DNA targets are often tumor-suppressor genes that are frequently silenced by methylation in cancer.

AP essay questions -

The ability of G-protein-coupled signaling pathways to undergo desensitization to receptor substances "tolerance" is part of the basis for addiction to opiates, caffeine, benzodiazepines and nicotine.

Thus, PTEN mutations which make the protein defective release two pathways which can lead to excess proliferation and thus to cancer. Neutrophils and macrophages immune system cells enter the wound and fight bacteria by creating toxic free radicals like hydrogen peroxide, peroxynitrite and the hydroxyl radical.

Antioxidant enzymes like selenium-containing glutathione peroxidase and thioredoxin reductase protect neutrophils, macrophages and other tissues from the free radicals intended to destroy pathogens. Macrophages release growth factors to promote tissue re-growth.

Continuous exposure to the free radical peroxynitrite leads to DNA mutation. Growth factors from macrophages promote proliferation of new cancer cells. Non-infectious causes of chronic inflammation such as tobacco smoke and asbestos also contribute significantly to cancer.

Although the main carcinogenic effects of inflammation are on tumor promotion and progression, chronic inflammation can also lead to tumor initiation. Septic shock is the main cause of multiple organ system failure, the leading cause of mortality in intensive care units.

During infection DNA damage in pathogens is beneficial, but in chronic inflammation the body's own cells become the victims.

The hyperproliferation associated with chronic inflammation leads not only to decreased genome stability and increased mutation, but to hypermethylation see Section F. There are also great differences in susceptibility to cancer between different organs and tissues, not all of which can be attributed to environmental differences.

Ap biology protein synthesis essay

Cancer results from DNA changes that re-direct cellular activity away from anything other than reproduction, growth and invasion of other tissues. Although cancer is a disease of DNA mutation, the vast majority of those mutations are acquired due to environmental influences especially chemical rather than by heredity.

It is, however, possible to inherit a predisposition to cancer which, nonetheless, requires additional environmental influences to become manifest. Were the gene not recessive, the embryo would quickly be consumed by cancer. Being recessive means that an additional mutation is required for the genes to become manifest.

But by already having one of the two mutations required for activity, the homozygous mutant conditions necessary for malfunctioning tumor suppressor protein becomes much more likely to occur.

The oncogenic DNA viruses consist of four main groups: Although adenoviruses can cause tumors in rodents, there is no evidence that they do so in humans. The Human PapillomaVirus HPV associated with cervical carcinoma is a papovirus that produces two oncoproteins, one of which binds to p53 protein and the other of which disrupts the action of the RB gene.

Insofar as both p53 and pRb are both tumor suppressor proteins that can stop the cell cycle, blocking the action of both proteins is a major step leading to cellular "immortalization" through telomerase usuallyor ALT Alternative Lengthening of Telomeres.

Hepadnaviruses infect the liver and thereby cause a large portion of the cancers seen in underdeveloped countries. Herpes simplex virus probably contributes urogenital and oropharangeal cancers. In developed countries the Epstein-Barr herpesvirus is associated with mononucleosis, a non-malignant form of lymphocyte proliferation.

But in wet sections of Africa Epstein-Barr causes Burkitt's lymphoma, the predominant cancer in the children of that region.

Cancer Death — Causes & Prevention

And in southern China Epstein-Barr is responsible for many cases of nasopharyngeal carcinoma. Although retroviruses and other RNA viruses contribute to cancer in animals, they rarely do so in humans except through indirect effects.

The HIV retrovirus is associated with cancer in AIDS patients, but most often this effect is due to reduced immune system action against herpesviruses.

Epigenetic Dysregulation Epigenetic refers to modifications of gene expression that occur without changes in DNA sequence.Pearson, as an active contributor to the biology learning community, is pleased to provide free access to the Classic edition of The Biology Place to all educators and their students.

Try Our Friends At: The Essay Store. Free English School Essays. We have lots of essays in our essay database, so please check back here frequently to see the newest additions.

The Online Writing Lab (OWL) at Purdue University houses writing resources and instructional material, and we provide these as a free service of the Writing Lab at Purdue.

1. INTRODUCTION - OVERVIEW - Biology as a science deals with the origin, history, process, and physical characteristics, of plants and animals: it includes botany, and zoology.

A study of biology includes the study of the chemical basis of living organisms, srmvision.com related sciences include microbiology and organic chemistry. Tumor-suppressor genes act primarily through their influence on the cell srmvision.com life cycle of a cell that divides can be described by a four-phase cell cycle composed of M phase, G 1 phase, S phase, and G 2 phase.

M phase is the phase of mitosis, when the cells physically divides.G 1 phase is the first Gap phase (or Growth phase), which occurs immediately after mitosis. Essay # 6. Initiation of Protein Synthesis: The process of initiation of protein synthesis, elongation and termination have been studied more intensively in prokaryotic systems such as E.

Ap biology protein synthesis essay

coli than in other protein-synthesizing entities (Fig. ).

Protein synthesis essay ap biology review